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AQP4 deficiency in mice leads to severe neuroinflammation, increased microglial activity, and neuronal damage [61]

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Theprincipal distinction between methyl-, ethyl-, andn-propyl-cobalamin lies in the relative stability of this MLCT state, with the terminal alkyl groups in ethyl and n-propyl acting as electron donors to destabilize the partial carbon anion in the MLCT state

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